肠炎患者的便微生物群移植:随机对照试验的系统审查和元分析
R Gefen1,2, J Dourado1, S H Emile1,3
1Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA.
Techniques in coloproctology
|April 17, 2025
概括
便微生物群移植 (FMT) 显示出诱导性结肠炎 (UC) 缓解的希望. 药物预治疗和口服或多捐赠者FMT的使用可能会提高缓解率.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 便微生物种移植 (FMT) 已被认为具有恢复肠道微生物组平衡的能力.
- 炎症性肠病,特别是性结肠炎 (UC),一直是FMT研究的重点.
- FMT的安全性概况通常是可以接受的.
研究的目的:
- 评估便微生物群移植 (FMT) 对于性结肠炎 (UC) 患者实现缓解的疗效.
- 确定影响UC治疗中FMT成功的因素.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 搜索内容包括PubMed,Scopus,谷歌学者,以及clinicaltrials.gov.gov等网站.
- 主要结局是联合临床和内镜缓解;次要结局包括个人缓解率和不良事件.
主要成果:
- FMT显著增加了联合临床和内镜缓解 (OR 2.25),临床缓解 (OR 2.02) 和内镜缓解 (OR 1.95) 的几率.
- 在FMT和对照组之间没有观察到不良事件或结肠炎发生率的显著差异.
- 使用生物药物,类固醇或甲状腺素的预治疗,以及口服FMT和多捐赠者FMT,与更高的缓解率有关.
结论:
- 便微生物群移植 (FMT) 是诱导性结肠炎 (UC) 缓解的有希望的治疗选择.
- 优化FMT协议,包括治疗前的策略和给药方法 (口服,多捐赠者),可能会改善临床结果.
- 需要进一步的研究来巩固FMT在UC管理中的作用.
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