产后抑郁症增加了儿童注意力缺陷多动性障碍的风险 诊断 诊断
Darios Getahun1,2, Michael J Fassett3,4, Nana A Mensah5,6
1Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, 2nd Floor, Pasadena, CA, 91101, USA. Darios.T.Getahun@kp.org.
Reproductive sciences (Thousand Oaks, Calif.)
|April 17, 2025
概括
经历产后抑郁症 (PPD) 的母亲的孩子有更高的发展注意力缺陷多动障碍 (ADHD) 风险. 这种关联在各种人口统计数据中观察到,表明PPD是早期多动症干预的潜在指标.
科学领域:
- 围产阶段精神病学 围产阶段精神病学
- 儿童神经学 儿童神经学
- 发育儿科 发育儿科
背景情况:
- 产后抑郁症 (PPD) 是一个重要的不良妊娠结果.
- 母亲PPD与后代注意力缺陷多动症 (ADHD) 发展之间的相关性需要进一步调查.
- 了解这种联系对于早期识别和干预策略至关重要.
研究的目的:
- 确定母亲产后抑郁症 (PPD) 是否会增加儿童注意力缺陷多动障碍 (ADHD) 的风险.
- 分析孩子的性别,种族/种族和妊娠年龄如何改变PPD和ADHD之间的关联.
- 在患有PPD母亲的孩子中识别ADHD的潜在早期预警信号.
主要方法:
- 一个回顾性队列研究,利用229,860个单独出生的电子健康记录.
- 纳入标准:3至12岁的儿童,出生于2010年01月01日至2019年31月31日之间.
- 使用ICD-9-CM/ICD-10-CM代码和药房记录确定PPD和ADHD;发生率和调整的危险比率 (aHR) 计算.
主要成果:
- 与没有PPD (5.18/1000人年) 相比,患有PPD的母亲的孩子患ADHD的发生率明显高 (8.85/1000人年),aHR为1.76 (95%CI:1.66-1.86).
- 在早产 (29-32周:aHR=1.61;33-36周:aHR=1.72) 的儿童中,PPD与ADHD风险增加有关.
- PPD与ADHD风险增加之间的关联在所有种族/族群和两性之间是一致的.
结论:
- 母亲产后抑郁症 (PPD) 与后代注意力缺陷多动症 (ADHD) 的风险增加有关.
- 后期多动症可能成为识别那些可以从早期多动症监测和干预中受益的儿童的有价值指标.
- 需要进一步的研究来阐明PPD和ADHD之间潜在的因果关系或共同的风险因素.
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