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Updated: May 11, 2025

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
08:27

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

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线粒体复杂性在ER-线粒体接触点通过PDZD8-FKBP8连接进行调节

Koki Nakamura1, Saeko Aoyama-Ishiwatari1, Takahiro Nagao1

  • 1Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, 113-8656, Japan.

Nature communications
|April 17, 2025
PubMed
概括

研究人员确定FKBP8是ER蛋白PDZD8的线粒体合作伙伴,形成了一个新的连接复合体. 这种复合体对于线粒体-ER膜接触部位 (MERCS) 至关重要,并调节线粒体形态.

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