PSYSCAN多中心研究:精神病临床高风险样本的基线特征和临床结果
Stefania Tognin1,2, Sandra Vieira1,3,4, Dominic Oliver5,6,7
1Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, De Crespigny Park, Denmark 458 Hill, SE5 8AF, London, UK.
Schizophrenia (Heidelberg, Germany)
|April 17, 2025
概括
在临床高风险 (CHR) 个体中预测精神病风险是复杂的. 该PSYSCAN项目整合了多样化的数据,发现CHR个体表现出异质性和超出精神病发作的结果,需要更广泛的预后模型.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 生物标志物研究 生物标志物研究
- 临床心理学 临床心理学
背景情况:
- 仅使用临床数据就很难准确预测临床高风险 (CHR) 个体的精神病发作.
- 该PSYSCAN项目通过整合多式联运数据以提高预测准确度来解决这一问题.
研究的目的:
- 通过整合临床,环境,神经成像,认知和外周血液生物标志物来改善CHR个体的预测结果.
- 为了评估24个月的临床和功能结果,在一个大型的,多站点的CHR队列中.
主要方法:
- 一个自然主义的,前性的研究设计跨越12个国际网站.
- 包括238名CHR个体和134名健康对照 (HC).
- 在多个时间点进行全面评估 (基线,3,6,12,18,24个月).
主要成果:
- 在人口统计和心理健康状况方面,CHR和HC组之间存在显著的基线差异,包括高的并发症率 (焦虑/情绪障碍).
- 在CHR组24个月内观察到10.5%的精神病过渡率.
- 总体而言,CHR组表现出功能改善和精神病症状减少,尽管异质.
结论:
- 人群CHR表现出显著的临床异质性和高率的并发性焦虑和情绪障碍.
- 在这项多中心研究中,精神病过渡率低于预期,符合最近的发现.
- 对于CHR个体的预后模型必须超出精神病发作范围,包括功能和跨诊断结果.
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