在没有光环的偏头痛中,胰岛子区域的结构和功能变化及其与疼痛感知的关系
Xiao Wang1,2, Xiaoyu Gao1, Xu Ouyang1
1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Scientific reports
|April 17, 2025
概括
偏头痛患者在背部前部岛内表现出结构性和功能性大脑变化,影响疼痛感知. 这些岛屿异常与偏头痛的频率,强度和持续时间有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 脑部成像 脑部成像
背景情况:
- 偏头痛是一种常见的神经疾病,与疼痛感知异常有关.
- 岛屿在疼痛处理中发挥着关键作用,但其在偏头痛中的具体变化尚未完全理解.
研究的目的:
- 为了调查在偏头痛没有光环 (MWoA) 患者的岛屿分区的结构和功能变化.
- 探索岛屿变化和偏头痛特征之间的关系.
主要方法:
- 使用基于voxel的形态测量 (VBM) 和基于种子的功能连接 (FC) 分析.
- 44名MWoA患者和51名健康对照进行了比较.
- 通过强度,频率和持续时间来评估疼痛感知.
主要成果:
- 患有MWoA的患者在双侧背部前胰岛 (dAI) 中的灰质体积减少.
- 观察到dAI/后面的insula和precuneus以及其他额头和部区域之间增加了FC.
- 在左dAI和前额/后额区域之间,以及白体之间,观察到CF降低.
结论:
- 这些发现支持了偏头痛中胰岛异常假设.
- 背部前岛的变化对于偏头痛患者的疼痛感知至关重要.
- 特定的岛屿子区域与偏头痛的复杂机制有关.
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