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Updated: May 11, 2025

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PP2A:B55与p107和Eya3的冷EM结构定义了基质招募

Sathish K R Padi1, Rachel J Godek2, Wolfgang Peti1

  • 1Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, CT, USA.

Nature structural & molecular biology
|April 17, 2025
PubMed
概括

蛋白酸酶2A (PP2A) 的特异性是通过独特的基质和调节器结合机制与其B55全酶实现的. 这些发现提供了针对PP2A:B55相互作用在细胞信号传递和癌症的治疗策略.

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Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
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