肝硬化指数和高血压之间的关系:NHANES 2011-2018年
Wenxuan Zhang1, Bing Gao2, Yaping Wang3
1Acupuncture and moxibustion and Massage College of Anhui University of Chinese Medicine, HF, China.
BMC cardiovascular disorders
|April 17, 2025
概括
肝硬化指数 (HSI) 显示了与高血压风险的U形联系. 高和意外低的HSI水平都可能增加高血压风险,这表明复杂的代谢联系.
科学领域:
- 代谢健康 代谢健康
- 心血管疾病研究研究
- 非侵入性诊断 非侵入性诊断
背景情况:
- 肝硬化指数 (HSI) 是评估肝脂肪的非侵入性工具.
- 代谢功能障碍,包括肝肥胖症,越来越多地与高血压有关.
- 抗胰岛素和炎症等机制可能将肝脂肪与血压升高联系起来.
研究的目的:
- 研究肝硬化指数 (HSI) 与高血压风险之间的关联.
- 通过使用先进的统计模型,探索HSI和高血压之间的关系的性质.
主要方法:
- 利用了NHANES数据库 (2011-2018) 中17501名成年人的数据.
- 使用阿胺转移酶 (ALT),阿斯巴酸氨转移酶 (AST) 和BMI计算的HSI.
- 采用单变量分析,加权多变量物流回归和受限制立方线 (RCS) 模型.
- 进行子组分析以验证发现.
主要成果:
- 在HSI和高血压之间观察到显著的U形关系 (P<0.001).
- 较高的HSI四分位数 (Q3,Q4) 显示高血压的几率增加 (ORs 2.29-4.03).
- 较低的HSI水平也表明高血压风险略有增加.
- 发现与教育,癌症和糖尿病有显著的相互作用.
结论:
- 肝硬化指数 (HSI) 显示了与高血压风险的U形关联.
- 在初级保健中,HSI可以作为高血压风险评估的实际查工具.
- 需要进一步的纵向研究来确认因果关系并阐明潜在的途径.
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