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IL-16在与年龄相关的骨肌肉缩中的作用:一项综合性研究

Wenliang Fan¹, Zhibang Zhao¹, Liqiang Wang¹

¹Emergency Trauma Center, Nanyang Second People's Hospital, No 66, East Jianshe Road, Nanyang, 473000, Henan, China.

BMC musculoskeletal disorders

|April 17, 2025

背景:

本研究旨在基于老年骨科患者及动物实验，探讨白细胞介素-16（IL-16）在肌肉减少症中的作用。

方法:

本研究中的临床研究为一项观察性研究，纳入了2021年1月至2022年1月期间因骨科创伤入住我科的所有老年患者。若患者同时存在握力降低（HGS）和四肢骨骼肌质量降低（ASM），则被诊断为肌少症。采用倾向性评分匹配（PSM）以减少混杂因素带来的偏倚，并比较肌少症患者与非肌少症患者血清IL-16水平的差异。在动物实验中，给予小鼠IL-16处理，以评估IL-16对肌肉功能和肌肉质量的影响；随后建立肌少症模型，并使用抗IL-16干预，以探讨靶向IL-16的潜在治疗作用。

结果:

共纳入421名个体进行临床研究，其中77名被诊断为肌肉减少症。在匹配的人群中，握力低、骨骼肌质量低及患有肌肉减少症的个体，其血清IL-16水平均显著高于正常个体（均P < 0.001）。经IL-16处理的小鼠表现出显著的肌肉功能与运动能力下降，并伴有肌肉质量的丢失。使用抗IL-16抗体可能逆转由A型肉毒毒素引起的肌肉减少症特征。

结论:

IL-16 水平较高的个体可能具有显著较高的肌少症风险。IL-16 会损害小鼠的肌肉功能和身体活动能力，并导致肌肉萎缩，而靶向干预 IL-16 可减轻这些效应。

关键词:

细胞因子 (cytokines) 是一种细胞因子.一个IL-16的IL-16是什么?燃烧起来的火焰肌肉缩肌肉缩肌肉缩萨尔科佩尼亚是什么意思萨尔科佩尼亚

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