软组织和骨外肉瘤的全球模式和负担:1990年至2021年的趋势
Mingxia Zhu1, Lan Zhang2, Yong Wei3
1Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
BMC cancer
|April 17, 2025
概括
全球软组织肉瘤负担在绝对数量上增加,但在年龄标准化率上下降. 差异仍然存在,强调需要公平地获得软组织和骨外肉瘤的护理.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 软组织肉瘤 (STS) 是一种罕见的恶性瘤,起源于连接组织.
- 本研究提供了从1990年到2021年对STS和骨外肉瘤的全球负担的系统评估.
研究的目的:
- 评估STS的发病率,死亡率和残疾调整寿命年 (DALYs) 的全球趋势.
- 分析不同社会人口统计指数 (SDI) 级别疾病负担的差异,并预测未来的趋势.
主要方法:
- 利用了2021年全球疾病负担研究 (GBD) 的数据.
- 雇佣年龄标准化率 (ASIR,ASMR,ASDR),估计年度百分比变化 (EAPC) 和不平等指标.
- 整合了分解分析,边界分析和贝叶斯年龄周期队列 (BAPC) 建模用于预测.
主要成果:
- 对于STS的全球年龄标准化发病率,死亡率和DALY率在1990年至2021年期间下降.
- 男人和老年人 (95岁以上) 的比例较高;高SDI地区的ASIR略有增加,但ASMR/ASDR下降.
- 高SDI和低SDI国家之间的疾病负担差距扩大;预测显示到2036年,绝对数字上升,但年龄标准化率下降.
结论:
- 尽管年龄标准化率下降,但全球绝对的STS负担正在增加.
- 在STS负担方面仍然存在显著的差异,强调需要改善医疗保健和有针对性的干预措施.
相关概念视频
02:07Tumor Progression
6.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.1K
01:21Cancer Survival Analysis
298
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
298
01:03Rous Sarcoma Virus (RSV) and Cancer
4.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
4.9K