治愈性或非治愈性:针对晚期黑色素瘤的免疫疗法
Richard Kelly1,2,3, Abigail Miller4, Rachel Roberts-Thomson4
1Paula Fox Melanoma and Cancer Center, The Alfred, Melbourne, Australia.
JNCI cancer spectrum
|April 18, 2025
概括
临床医生很少讨论接受免疫治疗的晚期黑色素瘤患者的治愈意向治疗 (CIT). 记录的CIT有很大的差异,影响了治疗方法和患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 临床医学 临床医学
- 医学研究 医学研究
背景情况:
- 历史上,晚期黑色素瘤被认为是无法治愈的,但免疫疗法提高了生存率.
- 临床医生讨论治疗意图,特别是"治愈",与晚期黑色素瘤患者的研究有限.
研究的目的:
- 检查接受免疫治疗的晚期黑色素瘤患者治疗意向讨论的频率和记录.
- 调查治疗意图是否影响免疫疗法选择和结果.
主要方法:
- 在278名接受免疫治疗 (2019-2023) 的不可切除或IV期黑色素瘤患者的多中心回顾性队列分析中.
- 电子医疗记录被用于识别同意接受治疗意图治疗 (CIT) 和非治疗意图治疗 (NCIT) 的患者.
主要成果:
- 只有12% (32/278) 的患者同意治疗意图治疗 (CIT).
- 接受CIT治疗的患者更有可能接受组合免疫疗法 (76%vs. 47%).
- 在澳大利亚各州之间观察到CIT率的显著区域差异 (14%对比0.8%).
结论:
- 对于晚期黑色素瘤患者来说,记录的治疗意图存在相当大的变化.
- 需要进一步的研究,以了解记录的治疗意图对患者管理和结果的影响.
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