在患有炎症性肠道疾病的患者中管理光线微生物生态的最新进展:从证据到基于微生物的诊断和个性化治疗
Erica Bonazzi1, Caterina De Barba1, Greta Lorenzon1
1Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Expert review of gastroenterology & hepatology
|April 18, 2025
概括
在炎症性肠病 (IBD) 中调查肠道微生物群揭示了它在疾病发展中的关键作用. 基于微生物组的个性化疗法正在成为IBD管理的有希望的方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,涉及慢性肠道炎症和异常免疫反应.
- 肠道微生物群在IBD的开始和进展中发挥着重要作用.
- 目前IBD的诊断和治疗策略越来越多地包含了以微生物为中心的个性化护理.
研究的目的:
- 审查当前对肠道微生物群在IBD中的作用的理解.
- 探索针对IBD的微生物组的诊断标记和治疗策略.
- 讨论将微生物组研究纳入临床实践,以进行个性化的IBD管理.
主要方法:
- 2004年至2024年间发表的综合文献综述研究.
- 优先考虑人类研究,并通过选择动物研究来补充机械洞察力.
- 包括来自主要科学数据库 (PubMed,Scopus,Web of Science) 的同行评审文章 (临床试验,系统评论,元分析).
主要成果:
- 该审查涵盖了管理IBD相关微生物群的机制,包括诊断微生物标志物.
- 讨论了新型疗法,如便微生物种移植,基于代谢物的治疗方法和精确微生物组调制.
- 研究了在临床环境中分析肠道微生物群组成和功能的技术.
结论:
- 基于个体微生物特征的个性化治疗策略显示出IBD治疗的巨大潜力.
- 将微生物组研究纳入临床实践的标准化整合对于提高IBD护理精度至关重要.
- 预计将转向基于微生物群的个性化医学来管理炎症性肠道疾病.
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