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Updated: May 12, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

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ERCnet:在基因复制存在的情况下,对相互作用网络的基因组预测

Evan S Forsythe1,2,3, Tony C Gatts4, Linnea E Lane2

  • 1Department of Integrative Biology, Oregon State University, Corvallis, OR, USA.

Molecular biology and evolution
|April 18, 2025
PubMed
概括

赋予基因功能是一项挑战. ERCnet是一个新的生物信息学工具,它使用进化速率共变 (ERC) 来预测蛋白质相互作用,并在全基因组分析中克服家族遗传不一致性.

关键词:
共同进化的共同进化进化速率的共同变化互动网络互动网络.互动的作用组.蛋白质相互作用 蛋白质相互作用

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Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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