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遗传差异化受限于具有更高基因流量的局部适应群体中的染色体反转和假定中间体

Maria Akopyan^1,2, Anna Tigano^3,4, Arne Jacobs^3,5

¹Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USA.

Molecular biology and evolution

|April 18, 2025

概括

基因组结构影响了适应,尤其是基因流动. 在大西洋银面体中,逆转和中间体在局部适应中发挥着关键作用,通过聚类差异化遗传位点.

科学领域:

进化生物学是进化生物学.
人口遗传学人口遗传学
基因组学就是基因组学.

背景情况:

基因组结构,包括结构变异和重组景观,显著影响了适应性和遗传多样性.
分化基因位点的聚类可以通过减少重组来维持局部适应的变异,这在基因流动的背景下尤其重要.
对非模型物种的有限基因组资源历来阻碍了对这些进化过程的研究.

研究的目的:

为了研究基因组结构如何影响大西洋银面地区的局部适应,非模型鱼物种.
探索基因流在形成全基因组差异化模式中的作用.
分析结构变化的贡献,如反向和中心区域对适应差异的贡献.

主要方法:

利用了新的参考基因组和大西洋银面的多重重组合地图.
分析了四个种群中168个个体的基因组数据,跨越一个度梯度.
采用种群遗传学分析,包括FT异常检测,以评估全基因组差异化和基因流动.

主要成果:

观察到全基因组分化的连续性从南向北增加,与更高度的基因流量减少相关.
发现增加的基因流与更高的FST异常位置的数量和聚类有关.
在含有反向的大型单元区内确定了差异化位置和接近中心区域,其序列分歧主要表现在反向中.

结论:

聚类基因组架构,特别是那些涉及逆转的架构,在高基因流下演变,并促进本地适应.
逆转与基因流动的适应分歧有很大关系.
中心层区域由于重组和多样性较低而表现出差异化,而不是高度的序列分歧,突出了不同的进化角色.

关键词:

基因组的分歧基因组的分歧地方适应地方适应再组合的复合方式.结构变化的结构变化.

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