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在GD-2抗体治疗中的眼睛毒性:一个案例研究

Brooke Fraser¹

¹Division of Pediatric Hematology/Oncology, Department of Pediatrics, Center for Children's Cancer and Blood Disorders, SUNY Upstate Medical University, Syracuse, NY, USA.

Journal of pediatric hematology/oncology nursing

|April 18, 2025

概括

像瞳孔这样的眼睛毒性是dinutuximab治疗神经母细胞瘤儿童的罕见副作用. 护理人员的早期识别和报告对于管理这些视觉不良事件至关重要.

科学领域:

儿科瘤学儿科瘤学
眼科医生眼科眼科
药理学药理学是指药理学的学科.

背景情况:

用GD-2抗体治疗神经母细胞瘤,如dinutuximab,很少会导致眼睛的毒性.
眼部不良事件,包括瞳孔,视敏度变化和光恐惧症,需要仔细监测.

研究的目的:

在接受dinutuximab治疗的儿童中呈现两例眼部毒性病例的临床表现和管理.
强调医疗保健提供者在识别和报告眼部不良影响方面的重要性.

主要方法:

一个用dinutuximab治疗高风险神经母细胞瘤的6岁男孩的案例研究.
眼科评估和用皮洛卡尔宾滴和太阳镜进行症状治疗.

主要成果:

患者经历了双边肌,视力敏度下降,并在dinutuximab治疗后出现光恐惧症.
皮洛卡尔平对光恐惧症提供了一些缓解,并改善了瞳孔反应,尽管视力敏度并没有完全恢复.
缺乏基线视觉查阻碍了精确的毒性评估,并且由于剂量修改的风险更大,治疗继续.

结论:

在开始GD-2抗体治疗之前,基线眼科查至关重要,以准确评估视觉变化.
与dinutuximab治疗相关的不太常见的眼部毒性可能未被报告,这需要医疗保健提供者改进识别和管理策略.

关键词:

免疫疗法免疫疗法神经母细胞瘤的神经母细胞瘤瘤学诊断诊断瘤学诊断诊断儿科癌症儿科癌症儿科瘤学儿科瘤学固体瘤是一个固体瘤.毒性的毒性毒性的毒性

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