关于乳腺癌妇女发展远程转移的危险因素的回顾性病例-队列研究
Serena Bertozzi1, Ambrogio Pietro Londero2,3, Giovanni Vendramelli1
1Breast Unit, University Hospital of Udine, ASUFC, Udine, Italy.
Cancer medicine
|April 18, 2025
概括
识别乳腺癌转移风险因素至关重要. 叶叶癌,三阴亚型,高等级和较大的瘤大小增加转移风险,而孕激素受体表达是保护性的.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 医学统计 医学统计
背景情况:
- 转移是乳腺癌死亡率的主要驱动因素.
- 了解风险因素是早期干预和改善患者结果的关键.
研究的目的:
- 确定乳腺癌患者远程转移的风险因素.
- 分析与转移发育有关的生存率.
- 探索局部复发和远程转移之间的联系.
主要方法:
- 对患有乳腺癌的妇女进行了回顾性病例-队列研究 (2001-2015年).
- 将患有远程转移的患者与未患有远程转移的患者进行比较.
- 分析患者特征,瘤生物学和治疗数据.
主要成果:
- 转移的重大风险因素包括叶囊侵入性癌症,三重阴性亚型,高瘤等级,较大的瘤大小,淋巴结参与和局部区域复发.
- 孕激素受体 (PR) 表达表明具有保护作用 (或0.52).
- 与对照组相比,转移患者的20年整体存活率 (23.62%) 显著低于对照组 (99.23%).
结论:
- 叶叶入侵性癌,特定的亚型,高等级,更大的瘤大小,淋巴结参与,以及局部区域的复发是确定的远程转移的风险因素.
- 孕激素受体表达是防止转移的保护因素.
- 机器学习显示了个性化转移风险评估乳腺癌的潜力.
更多相关视频
08:41Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
Published on: July 29, 2017
13.8K
09:44Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
Published on: June 13, 2016
8.4K
相关概念视频
01:21Cancer Survival Analysis
298
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
298
02:30Metastasis
5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K