异常机械应力对关节软骨,下骨和圆盘的不同影响
1The First Department of Oral and Maxillofacial Surgery & Oral Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, China.
Frontiers in physiology
|April 18, 2025
概括
关节疾病 (TMJD) 涉及由于关节 (TMJ) 发生异常机械力而引起的疼痛和功能障碍. 了解TMJ软骨,骨和磁盘对机械压力的反应是管理这种常见的口腔和大面部疾病的关键.
科学领域:
- 生物机械工程 生物机械工程
- 口腔和牙面部外科手术
- 软骨生物学 软骨生物学
背景情况:
- 关节疾病 (TMJD) 呈现出疼痛,问题和口腔开口受限,影响关节 (TMJ).
- 肌关节的功能就像一个生物机械系统,翻译口力,随着状软骨经历机械刺激的影响重塑.
- 功能失调的机械刺激是导致关节结构异常的重要因素.
研究的目的:
- 审查关节软骨,底骨和关节盘对不同类型和强度的异常机械刺激的重塑反应.
- 专注于异常机械力量对关节骨下骨和关节盘在关节内的影响.
主要方法:
- 文献综述专注于研究机械刺激对关节部件的生物机械和结构影响.
- 分析详细研究TMJ软骨,底骨和磁盘对机械侮辱的细胞和矩阵反应的研究.
主要成果:
- 异常的机械压力会引发状软骨的退化,标志着状细胞活动的改变,亡的增加和细胞外矩阵的损伤.
- 关节状软骨对机械负荷变化的适应能力由年龄和机械刺激的特征等因素调节.
- 底骨通常表现出骨质损失作为对异常机械力的初始反应.
- 在异常的机械刺激下,关节盘容易受到营养供应受损和矩阵新陈代谢变化的影响.
结论:
- 异常的机械负荷显著影响关节结构,导致软骨退化,底骨变化和磁盘矩阵变化.
- 关节元件对机械应力的重塑反应是复杂的,受到多种因素的影响,突出显示了对关节病因和治疗的进一步研究的需要.
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