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在直肠癌患者的直肠粘膜的改变微生物群

Hao Zhang^1,2, Yan Zhou², You-Heng Jiang³

¹Department of Laboratory Medicine, Hangzhou Geriatric Hospital, Hangzhou 310022, Zhejiang Province, China.

World journal of gastroenterology

|April 18, 2025

概括

结直肠癌 (RC) 患者表现出改变的肠道微生物群,具有特定的细菌比率,如Prevotella与Ruminococcus,可能作为诊断生物标志物. 这项研究强调了直肠粘膜微生物群在RC发展中的作用.

科学领域:

微生物学微生物学
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

微生物群失调与结直肠癌 (CRC) 的进展有关.
在直肠癌 (RC) 患者的直肠粘液微生物群上存在有限的研究.
这项研究调查了中国RC患者的直肠粘膜微生物群.

研究的目的:

探索与RC相关的直肠粘膜菌群变化.
为了确定微生物种群生物标志物用于RC诊断.

主要方法:

分析了72名RC患者和71名健康对照 (发现队列) 的直肠粘膜样本.
使用了22名RC患者和60名健康对照的验证队列.
采用了16S核糖体DNA基因测序,培养和定量PCR.

主要成果:

RC患者表现出改变的直肠粘膜微生物群,其丰富性和多样性增加.
在癌症组织中观察到蛋白质菌和热菌的枯竭,细菌菌和菌菌的丰富.
特定的微生物比率 (Prevotella/Ruminococcus,Prevotella stercorea/Propionibacterium acnes) 显示出具有诊断潜力.

结论:

结直肠癌患者具有改变的结直肠粘膜微生物群组成.
普雷沃特拉与鲁米诺可克的比率可以作为RC诊断的潜在生物标志物.
菌与Propionibacterium acnes的比率也可能是RC的有用诊断标志物.

关键词:

基因组学就是基因组学.我们的肠道微生物群.粘膜相关的微生物群预测性生物标志物预测性生物标志物这是直肠癌.

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