杆菌感染与代谢功能障碍和相关的脂肪性肝病有关:一项大型横截面研究
1Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang 330008, Jiangxi Province, China.
World journal of gastroenterology
|April 18, 2025
概括
杆菌感染与肥胖,高葡萄糖和成人血压有关. 高密度脂蛋白 (HDL) 显示出对这些代谢障碍的保护作用.
科学领域:
- 代谢健康 代谢健康
- 传染性疾病 传染性疾病
- 肝病学 肝病学是一种肝病学.
背景情况:
- 杆菌 (H. pylori) 感染影响全球一半的人口,并且越来越多地与肥胖和MASLD等代谢障碍有关.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球近四分之一的成年人,并与代谢综合征有共同联系.
- 这些联系的机制假设,如氧化应激和炎症,存在,但缺乏对多因素代谢关联的大规模研究.
研究的目的:
- 在中国成年人中调查H. pylori感染与肥胖,葡萄糖,脂质和血压之间的关联.
- 探索H. pylori感染和MASLD之间的关系.
- 为了确定H. pylori感染的背景下代谢障碍的独立风险因素.
主要方法:
- 研究了一组由28624名中国成年人组成的队列.
- 使用13C尿素呼吸试验确定了H. pylori感染.
- 腹部超声波诊断了MASLD,多变量逻辑回归分析了代谢因子关系.
主要成果:
- 感染H. pylori的发病率为26.8%,在老年人和肥胖的人群中更高.
- 阳性H. pylori的个体表现出血糖,LDL胆固醇和血压升高.
- 在MASLD患者中,H. pylori感染与葡萄糖,总胆固醇,BMI和血压的增加有关.
结论:
- H. pylori 感染与老年,肥胖,葡萄糖升高和腹筋血压有关.
- 高密度脂蛋白 (HDL) 显示出对H.pylori感染的保护作用.
- 这些发现强调了H. pylori在代谢障碍和MASLD中的作用.
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