使用1.3-μm和1.7-μm光学连贯性断层扫描对活体人类尾细胞进行成像
Jack C Tang1, Dorothy W Pan1, John S Oghalai1,2
1University of Southern California, Caruso Department of Otolaryngology-Head and Neck Surgery, Los Angeles, California, United States.
Journal of biomedical optics
|April 18, 2025
概括
光学连贯断层扫描 (OCT) 现在可以通过耳囊对人耳进行成像,为诊断听力损失提供了新的可能性. 1.3和1.7微米的OCT都有效地可视化了耳结构,1.7微米显示了清晰度的边际改善.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物医学成像技术 生物医学成像技术
- 眼科医生 眼科 眼科
背景情况:
- 人的耳软组织对于听力至关重要,但不能用当前的临床成像方法可视化.
- 感觉神经听力损失通常涉及到这些关键的耳结构的损伤.
- 光学连贯性断层扫描 (OCT) 已在成像小动物内方面展现出前途.
研究的目的:
- 为了确定OCT是否可以通过完整的耳囊成像人类耳.
- 为了比较1.3微米和1.7微米OCT对成像耳微观结构的疗效.
- 评估1.7微米的减少散射是否比1.3微米的OCT提供了优势.
主要方法:
- 开发了用于1.3微米和1.7微米波长的OCT干扰仪.
- 在两种系统中使用了相同的样本和参考臂光学.
- 影像化固定 ex-vivo 人类骨与完整的带,允许无波长切换.
主要成果:
- 无论是1.3微米还是1.7微米的OCT都成功通过眼囊进行成像,可视化了耳结构.
- 在某些情况下,由于减少了多重散射,1.7微米的OCT提供了更清晰的图像.
- 识别了耳结构,包括两波长的侧壁和内部梯形.
结论:
- OCT是一种可行的方法,可以通过耳囊对人耳进行成像.
- 这种技术有可能在体内测量耳功能,如振动计和血流.
- 虽然1.7μm OCT在图像清晰度方面显示出边际优势,但这两种波长都是有效的.
关键词:
一个的子.内耳的内耳,就是内耳的内耳.光学连贯性断层扫描 (optical coherence tomography) 是一种光学连贯性断层扫描技术.耳鼻喉科 耳鼻喉科 耳鼻喉科耳道学 耳道学是指耳道学.更多相关视频
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