相关实验视频
Updated: Jun 24, 2026

09:41
Calibrated Forceps Model of Spinal Cord Compression Injury
Published on: April 24, 2015
可卡因和胺诱导的副脊椎肌肉区综合征
Thomas Saliba1, Simone Giglioli2, Sanjiva Pather1
1Department of Imaging, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Turkish journal of emergency medicine
|April 18, 2025
概括
本案例报告详细介绍了一名年轻男子在娱乐性药物使用后罕见的腰椎副脊隔膜综合征的病例. 及时诊断和手术切除带术使她从这种危急状况中完全康复.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 腰椎副脊隔膜综合征是一种罕见的疾病,通常伴有背痛和潜在的肌肉缺陷.
- 虽然通常与强度炼有关,但与娱乐性药物使用,特别是可卡因和胺相关的病例正在出现.
- 有关肌肉衰竭的疾病 - - 拉布多米解,是可卡因和胺的已知并发症,导致肌酸激酶 (CK) 水平升高.
研究的目的:
- 报告一个罕见的腰椎脊隔膜综合征病例.
- 突出娱乐性药物使用的潜在作用,包括可卡因和胺,在这种情况的发展.
- 强调这种罕见病理的诊断和管理策略.
主要方法:
- 一个25岁的男性在使用可卡因,胺酸和酒精后出现严重的背痛的案例研究.
- 最初的诊断工作包括血清肌酸激酶 (CK) 水平和非对比的腹部计算机断层扫描 (CT).
- 随后进行了对比度增强CT,肌内压力测量和外科带切除.
主要成果:
- 患者出现了扩散肌肉疼痛和CK水平升高,最初怀疑是压碎综合征.
- 疼痛局限于副脊柱区域,CT显示肌肉胀和胀,表明隔间综合征.
- 肌内压力测量证实了隔间综合征,导致了成功的手术断层切除和恢复.
结论:
- 腰椎副脊隔膜综合征是一种极其罕见但严重的疾病.
- 娱乐性药物使用,特别是可卡因和胺,可以导致拉布地质溶解,并可能导致隔间综合征.
- 早期识别,适当的成像 (CT,MRI),压力测量和手术干预 (筋切割) 对于有利的结果至关重要.
相关概念视频
Classification of Skeletal Muscle Relaxants
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Depolarizing Blockers: Mechanism of Action
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
Depolarizing Blockers: Pharmocokinetics
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
Skeletal Muscle Relaxants: Adverse Effects
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
Skeletal Muscle Relaxants: Therapeutic Uses
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Tetanus
Tetanus is a life-threatening neurological disorder characterized by persistent muscle contractions and spastic paralysis. It is caused by Clostridium tetani, a motile, Gram-positive, rod-shaped, obligate anaerobe. These bacteria produce terminal endospores, giving them a distinctive “lollipop” or “tennis-racket” appearance. They thrive in anaerobic environments, such as those found in deep puncture wounds.Once introduced into the body, the spores germinate into vegetative cells. These cells...

