由于使用阿洛普林醇而引起的急性免疫过敏性肝炎
Carolyn Brooks1, Lucie Calderon2, Marina Mosunjac3
1Department of Internal Medicine, Emory University School of Medicine, Atlanta, USA.
Hepatology forum
|April 18, 2025
概括
阿洛普林醇可以导致严重的肝损伤和DRESS综合征,特别是在具有HLA-B58*01基因的患者中. 早期的皮质类固醇治疗对于控制这些阿洛普林醇诱导反应至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床药理学 临床药理学
- 免疫皮肤学 免疫皮肤学
背景情况:
- 急性免疫过敏性肝炎是一种药物诱导的肝损伤,通常表现为发烧,皮疹和腹痛.
- 氨醇是已知的药物诱导的肝损伤的原因,包括严重的免疫过敏性肝炎和DRESS综合征.
- HLA-B58*01基因是所有普林醇诱导的肝损伤的重要危险因素.
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