息性手术在患有EGFR突变性肺腺癌和多性转移的患者中是有效的
Yue Liu1, Yifei Zhou1, Shuangyi Li1
1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Translational lung cancer research
|April 18, 2025
概括
息性手术与表皮生长因子受体 - 铁氨酸激酶抑制剂 (EGFR-TKI) 治疗相结合,改善了EGFR突变肺腺癌和多叶性转移患者的无进展生存率. 这表明,选定的患者可能会在向治疗的同时从外科干预中受益.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 医学遗传学 医学遗传学
背景情况:
- 胸腔转移在EGFR突变肺腺癌 (EGFR-LUADm) 中很常见.
- 对这些患者的息性手术的作用进行了辩论.
- 针对性治疗后,胸腔病变的完全缓解是关键考虑因素.
研究的目的:
- 为了评估IVA阶段EGFR-LUADm患者患有多发性转移的性手术的益处.
- 为了确定手术是否改善了通过向治疗实现缓解后的结果.
主要方法:
- 对134名IVA阶段EGFR-LUADm肺部转移患者进行了回顾性研究.
- 接受EGFR-氨酸激酶抑制剂 (TKI) 单疗的手术与非手术组的比较.
- 倾向性得分匹配 (PSM) 用于最大限度地减少选择偏差;Kaplan-Meier和日志等级测试用于生存分析.
主要成果:
- 13名患者接受了息性手术,121人没有.
- 在PSM之后,13名手术和26名非手术患者进行了比较.
- 手术组的无进展生存期 (PFS) 显著改善 (中位数为43个月与11个月,P<0.001).
结论:
- 息性手术与EGFR-TKI治疗相结合,可以在多转移性EGFR-LUADm中延长PFS.
- 一个EGFR-LUADm患者的小组,有多发性转移,可能是缓解性手术的合适候选人.
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