血液度用于诊断登革热出血性发烧:来自斯里兰卡农村地区观察性研究的证据
Chamara Sarathchandra1,2, Ruwanthi Bandara1, Kosala Weerakoon3
1Teaching Hospital Anuradhapura, Anuradhapura, 50000, Sri Lanka.
概括
在关键阶段,在住院登革热患者中没有观察到血红素的20%增加. 这一发现质疑了世界卫生组织诊断登革热出血热 (DHF) 的标准的可靠性.
科学领域:
- 临床医学 临床医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 世界卫生组织 (WHO) 诊断登革热出血性发烧 (DHF) 的标准包括血红素水平增加20%.
- 这项研究调查了斯里兰卡农村住院登革热患者的血红素水平.
研究的目的:
- 为了比较在入院登革热患者的临床血红素水平,临界阶段开始和临界阶段期间的最大值.
- 评估世卫组织20%血红素增加标准的可靠性,以诊断大肠炎.
主要方法:
- 对入院登革热患者进行观察性研究,这些患者进展到关键阶段.
- 定期监测血红素水平和超声波扫描,特别是当血小板数下降到100,000/μl以下时.
- 超声波检测到的血泄漏证实了临界阶段的开始.
主要成果:
- 分析了43名患者;在基线和临界阶段发病之间没有发现血红素显著差异 (p=0.14).
- 没有一个患者在临界阶段开始时表现出血红素水平20%的增加.
- 观察到的最大血红素水平增加为17.0%.
结论:
- 没有观察到20%的血红素水平增加,这表明其在住院患者中诊断DHF的不可靠性.
- 该研究建议重新评估世卫组织诊断登革热血泄漏的标准.
- 频繁的超声波扫描可能为早期血泄漏检测提供更可靠的方法.
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