欧米茄-3脂肪酸对抗癌疗法诱导的口腔粘膜炎的影响:元分析
Xuan Tang1, Wenxi Li2, Qianmei Zhong2
1Otolaryngology Department, Mianyang Central Hospital, Sichuan, China.
Nutrition and cancer
|April 18, 2025
概括
欧米茄-3脂肪酸显著降低了接受治疗的癌症患者的严重口腔粘膜炎 (OM) 和OM相关的疼痛. 虽然这项干预措施没有减少OM的总体发病率,但通过减轻严重症状,它改善了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 临床研究 临床研究
背景情况:
- 口腔粘膜炎 (OM) 是癌症疗法的衰弱副作用.
- OM显著影响患者的生活质量和治疗坚持.
- 有效的OM预防和治疗策略至关重要.
研究的目的:
- 评估omega-3脂肪酸在预防和治疗癌症患者口腔粘膜炎的疗效.
- 分析omega-3脂肪酸对整体和严重OM发生率的影响.
- 评估omega-3脂肪酸对OM相关疼痛的影响.
主要方法:
- 五项涉及337名接受抗癌治疗的癌症患者的研究的元分析.
- 在主要数据库 (PubMed,Embase,Web of Science等) 进行系统的文献搜索. 在2024年9月24日之前.
- 使用95%置信区间 (CI) 计算风险比率 (RR) 和标准化平均差异 (SMD).
主要成果:
- 欧米茄-3脂肪酸并没有显著降低OM的总体发病率 (RR 0.50,95% CI 0.25-1.01).
- 观察到严重的OM发生率显著减少 (RR 0.31,95% CI 0.17-0.56) 没有异质性.
- 欧米茄-3脂肪酸显著缓解了与OM相关的疼痛 (SMD-1.61,95% CI-2.79至-0.43),没有异质性.
结论:
- 欧米茄-3脂肪酸有效降低癌症患者严重口腔粘膜炎的发生率.
- 欧米茄-3脂肪酸在缓解与口腔粘膜炎相关的疼痛方面具有显著的益处.
- 这一元分析支持使用omega-3脂肪酸作为治疗选择,用于治疗严重的OM和瘤患者的相关疼痛.
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