肠道菌 (Muribaculum intestinale) 通过将酸盐转化为酸盐来限制沙门氏菌 (Salmonella Typhimurium) 的殖民
Zhenyu Wang1, Shuaishuai Kang1, Zhenhua Wu1
1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
The ISME journal
|April 18, 2025
概括
饮食纤维缺乏会损害肠道健康和殖民抵抗力 (CR). 补充肠道菌 Muribaculum 或其代谢物propionate 增强了对沙门氏菌 Typhimurium 感染的CR.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 免疫学 免疫学 免疫学
背景情况:
- 饮食纤维摄入量不足与肠道失调和减少对肠道感染的殖民抵抗 (CR) 有关.
- 连接光纤剥夺与受损CR的确切机制尚不清楚.
- 了解这种关系对于公共卫生至关重要,尤其是在西方饮食方面.
研究的目的:
- 研究饮食纤维缺乏对肠道微生物群和CR的影响.
- 确定特定的微生物参与者和参与CR的代谢途径.
- 探索肠道感染的潜在治疗干预措施.
主要方法:
- 使用了一种感染沙门氏菌Typhimurium的小鼠模型.
- 采用饮食操纵 (缺乏纤维和补充),便微生物种移植 (FMT) 和基因组分析.
- 评估了肠道微生物组合的变化和CR.
主要成果:
- 缺乏食纤维导致CR受损,Muribaculaceae细菌的数量减少.
- 鉴定出Muribaculum intestinale作为一个关键的细菌,可以将糖酸转化为酸.
- 口服M. intestinale或酸补充剂恢复了针对S. Typhimurium的CR.
结论:
- 食纤维对于维持肠道微生物组平衡和殖民抵抗力至关重要.
- 代谢途径涉及M. intestinale的糖酸转化为酸,这对于CR来说至关重要.
- 酸补充剂代表了一个潜在的策略,以提高CR在人群中低纤维摄入量.
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