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含有menaquinone-7的Limosilactobacillus reuteri改善了卵巢切除小鼠的骨生物力学和微观架构:初步研究

Thaís Aguiar Santos¹, Jaqueline Lemes Ribeiro¹, Luisa Souza Battistelli¹

¹Institute of Science and Technology, São Paulo State University (Unesp), Av Engenheiro Francisco José Longo, 777, Jardim São Dimas, São José Dos Campos, SP, CEP: 12245-000, Brazil.

Journal of bone and mineral metabolism

|April 18, 2025

概括

在雌激素缺乏的小鼠中,Limosilactobacillus reuteri (LR) 和menaquinone-7 (MK-7) 改善了骨健康. 组合疗法显示出协同效应,增强骨的生物力学和结构,改善了LR生存率在体外.

科学领域:

骨生物学和微生物组研究.
研究肠道细菌与骨健康之间的相互作用.

背景情况:

雌激素缺乏,通常是由卵巢切除引起的,导致显著的骨损失和骨折风险增加.
像Limosilactobacillus reuteri (LR) 和维生素K2 (menaquinone-7, MK-7) 这样的益生菌因其潜在的骨保护作用而受到探索.

研究的目的:

评估Limosilactobacillus reuteri (LR) 和menaquinone-7 (MK-7) 单独和组合对小鼠卵巢切除诱导的骨损失的疗效.
评估MK-7对LR细菌生长在体外的影响.

主要方法:

卵巢切除术 (OVX) 的小鼠被用LR,MK-7或它们的组合治疗了4周.
评估的参数包括股骨生物力学,脊椎微型架构,骨素,奥克卢丁/Jam3表达和肠道组织形态测量.
在体外研究中,使用光密度和殖民地形成单位数量评估了MK-7的LR生长.

主要成果:

无论是LR还是MK-7,特别是结合起来,都显著改善了股骨的生物力学特性和脊椎厚度.
综合治疗对弹性模量和增加的脊椎体积和肠/密室比率产生了协同效应.
LR和MK-7组合恢复了脊椎椎微架构到假的水平;在体外,MK-7提高了LR的生存率.

结论:

在雌激素缺乏的小鼠中,Limosilactobacillus reuteri (LR) 和menaquinone-7 (MK-7) 有效地改善了骨的生物力学和微观结构性质.
建议LR和MK-7的协同预防作用用于雌激素缺乏的骨损失.
在MK-7的存在下,提高LR的体外存活率可能有助于观察到的体内益处.

关键词:

利莫西拉克托巴西勒斯 (Limosilactobacillus reuteri) 是一种植物.在MK-7中,MK-7是MK-7.梅纳金-7是什么意思骨质疏松症是一种骨质疏松症.维生素K2 维生素K2 是一种维生素.

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