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在同一结节内同步呈现肝炎性伪瘤和肝细胞癌:一个病例报告

Fanny Kamarudy Lay¹, Monica Bernasconi¹, Luigi Maria Terracciano^1,2

¹Unit of Pathology, IRCCS Humanitas Research Hospital, Rozzano, Via Manzoni 56, 20089, Milan, Italy.

Virchows Archiv : an international journal of pathology

|April 18, 2025

概括

本案例研究详细介绍了一种罕见的肝炎性伪瘤 (IPT) 与肝细胞癌 (HCC) 同时发生的情况. IPT可能是对之前的肝活检和真菌感染的反应性反应.

科学领域:

肝病学肝病学是一种肝病学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

肝炎性伪瘤 (IPT) 是一种罕见的良性肝病变.
IPT通常呈现为具有状细胞和炎症透的质量形成病变.
肝脏IPT与原发性肝脏恶性瘤的同步发生非常罕见.

研究的目的:

报告肝脏IPT与肝细胞癌 (HCC) 同时发生的独特病例.
在HCC和之前的肝脏活检的背景下调查IPT的潜在病因.
通过全面的评估来突出诊断挑战,并通过全面的评估来确认发现.

主要方法:

肝脏组织的组织学检查.
免疫组织化学染色用于表征细胞组件.
分子分析以识别传染病原体.
对患者病史的审查,包括之前的肝活检程序.

主要成果:

一名66岁的男性出现了同步的肝脏IPT和HCC.
在HCC的外围发现了IPT.
组织学,免疫组织化学和分子分析确定了真菌感染 (Cystobasidium slooffiae),并建议对先前的活检创伤产生反应性炎症反应是IPT的原因.

结论:

这一案例代表了肝脏IPT与HCC共存的事实例.
据推测,IPT是因阳性创伤 (肝脏活检) 和真菌感染而导致的二次反应性炎症过程.
综合性诊断评估对于将IPT与其他肝病变区分开来,并确定潜在原因至关重要.

关键词:

肝细胞癌是肝细胞癌.感染感染感染炎症性伪瘤是一种假瘤.肝脏肝脏肝脏肝脏

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