自我和告密者报告 认知衰退 不一致和轻度认知障碍 诊断
Anna Aaronson1,2, Adam Diaz1,3, Miriam T Ashford1,3
1Veterans Affairs Advanced Imaging Research Center, San Francisco Veteran's Administration Medical Center, San Francisco, California.
JAMA network open
|April 18, 2025
概括
参与者和研究伙伴报告认知能力下降之间的差异有效地识别轻度认知障碍 (MCI). 没有衰退的协议表明MCI的可能性较低,有助于排除认知障碍.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 来自参与者-研究伙伴对象的主观认知和功能衰退报告可以评估认知障碍风险.
- 自我报告的准确性可能受到轻度认知障碍 (MCI) 和痴呆症患者缺乏意识的限制.
研究的目的:
- 调查自我和研究伙伴报告的认知/功能衰退和MCI诊断之间的矛盾之间的关联.
主要方法:
- 这是一项横截面研究,利用阿尔茨海默病神经成像计划 (ADNI) 中的921名参与者-研究合作伙伴二极管的基线数据和大脑健康注册表电子验证在线方法研究 (eVAL) 中的279个二极管.
- 参与者和研究伙伴完成了日常认知量表 (ECog).
- 一个回归模型被开发和验证,以区分认知正常 (CU) 和MCI个体.
主要成果:
- 经验证的模型将CU与MCI区分开来,曲线下的面积为0.87,灵敏度为0.50,特异性为0.97.
- 该模型纳入了ECog分数不一致性,参与者人口统计,研究伙伴人口统计和抑郁症状.
- 参与者和研究合作伙伴对没有观察到的变化达成的协议与MCI的可能性较低有关.
结论:
- 测量ECog分数不一致性有效地区分认知不受损和MCI高特异性的个体.
- 两极不一致度指标对于在各种环境中排除MCI是有价值的.
- 参与者和研究伙伴之间关于缺乏认知变化的协议与MCI的可能性降低有关.
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