在深前叶角膜增生前角膜新血管化的治疗方法
Shabnam Mansur1, Albert Y Cheung2,3
1Northeast Ohio Medical University, Rootstown, OH.
Cornea
|April 18, 2025
概括
对于角膜新血管化 (CNV) 的DALK前治疗有效地减少了手术内出血. 虽然这些疗法在深前层状角膜成形术 (DALK) 后最大限度地减少了大血管复发,但一些中枢血管复发仍可能需要进一步的干预.
科学领域:
- 眼科医生 眼科 眼科
- 角膜外科手术 角膜外科手术
- 血管生物学 血管生物学
背景情况:
- 角膜新血管化 (CNV) 由于外科界面的原因,在深前层层层角膜整形术 (DALK) 期间存在手术内挑战.
- 对于成功的DALK结果而言,有效管理先前存在的CNV至关重要.
研究的目的:
- 评估DALK前治疗中枢神经炎的疗效,以减少手术内和术后并发症.
- 评估CNV治疗对DALK手术中出血,复发和移植存活率的影响.
主要方法:
- 对接受DALK治疗的患者以先前存在的CNV.进行回顾性图表审查.
- 在DALK之前治疗了CNV的眼睛 (用亚结合体贝瓦西祖马布/德克萨米沙[ABD]和/或米托米辛静脉化学栓塞[MICE]) 和未治疗的眼睛之间的结局的比较.
- 分析手术期间的并发症,手术后的中枢神经瘤复发,以及角膜整形术的排斥/失败.
主要成果:
- 中枢神经瘤治疗组经历了明显较少的手术内出血 (P = 0.024),没有出血相关的并发症或接口血液.
- 在接受MICE (100%) 和ABD (17%) 治疗的眼睛中,发现成功实现大气泡 (BB) 的困难.
- 在手术后,治疗组中的4只眼睛出现了心血管复发,尽管在大多数情况下大口径血管没有复发;2名患者需要额外的ABD后DALK.
结论:
- 在DALK之前的CNV治疗有效地减少了DALK期间手术内出血和大口径血管的复发.
- 在DALK之后,CNV的复发是可能的,可能需要继续管理和治疗.
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