鞭毛体内运输列车可以切换轨道,并沿着完好无损的初级毛囊中的多个微管道移动
Shufeng Sun1, Biqing Liang2, Adam Koplas1
1Wadsworth Center, New York State Department of Health, Albany, NY 12237.
概括
初级眼中的内传输 (IFT) 列车与运动性眼相比,表现出不同的运动行为. 这些列车可以切换微管,并在碰撞时暂停,影响信号分子的分布.
科学领域:
- 细胞生物学 细胞生物学
- 分子电机分子电机
- 乳生物学的生物学
背景情况:
- 内运输 (IFT) 对状细胞的结构和功能至关重要,涉及前向和后向的货物运动.
- 移动的眼利用偏好的微管协会来防止IFT列车碰撞.
- 主要毛有不同的微管结构,这对IFT列车导航构成了挑战.
研究的目的:
- 调查IFT列车在初级眼中的运动动态.
- 为了比较IFT训练的行为,在初级毛与移动的毛.
- 了解IFT列车相互作用如何影响信号分子分布.
主要方法:
- 在初级眼中IFT列车的活细胞成像.
- 分析IFT列车与微管双胞胎相互作用的分析.
- 观察IFT列车暂停和接触时的速度变化.
主要成果:
- 初级毛中的IFT列车与两个微管子管没有偏好地相互作用.
- 前行和后行IFT列车可以切换微管并与多个微管相互作用.
- IFT列车碰撞导致不可避免的暂停和改变的运动速度.
结论:
- 由于微管架构,IFT火车运动在初级乳毛中与运动乳毛不同.
- 碰撞引起的暂停和速度变化是初级毛的特征行为.
- 这些发现为了解初级乳毛中信号分子分布提供了基础.
相关概念视频
Microtubule Associated Motor Proteins
7.5K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
7.5K
Mechanism of Ciliary Motion
3.5K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.5K
Microtubules in Cell Motility
3.1K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
3.1K
Microtubules in Signaling
1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
The Movement of Organelles and Vesicles
4.3K
In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
4.3K
Assembly of Complex Microtubule Structures
1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K


