在上皮活体固体中的集群和巨大的波动
Yuan Shen1, Jérémy O'Byrne2, Andreas Schoenit1
1Université Paris Cité, CNRS, Institut Jacques Monod, Paris F-75013, France.
概括
表皮细胞表现出一种新的固体集群行为,连贯地作为一个活跃的极性固体而不是流体移动. 这一发现揭示了对组织完整性和集体细胞迁移动态的新见解.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
- 软物质物理学 软物质物理学
背景情况:
- 集体上皮细胞运动对于发育和疾病至关重要.
- 在上皮细胞中大规模聚集主要被建模为类似流体的.
- 未充分探索的集体运动模式可能会影响组织完整性.
研究的目的:
- 识别和描述大规模集体上皮质细胞运动的新模式.
- 为了研究表皮细胞集体行为超出流体动力学的物理性质.
- 了解不同集体运动阶段对组织完整性的影响.
主要方法:
- 在不同类型的上皮细胞中进行体外单个细胞跟踪.
- 分析细胞运动模式,密度波动和速度相关性.
- 基于活性极性固体框架的理论建模.
主要成果:
- 确定了一个独特的集体细胞运动模式:极地活性固体群.
- 观测到远距离的极地顺序,无尺度的速度相关性和剪切波.
- 在大型系统中展示了不同的弹性变形波动,表明了破裂的可能性.
结论:
- 表皮细胞可以表现出固体状的集体运动,具有独特的物理特征.
- 在活跃的极性固体中,无质量定向的戈德斯通模式驱动着观察到的现象.
- 固体群动力学可能导致大规模组织破裂和完整性丧失.
相关概念视频
Cell Motility through Blebbing
1.8K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
1.8K
Colloids and Suspensions
1.6K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
1.6K
Actin Polymerization and Cell Motility
5.0K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.0K


