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相关概念视频

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Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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相关实验视频

Updated: May 11, 2025

Visually Based Characterization of the Incipient Particle Motion in Regular Substrates: From Laminar to Turbulent Conditions
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在上皮活体固体中的集群和巨大的波动.

Yuan Shen1, Jérémy O'Byrne2, Andreas Schoenit1

  • 1Université Paris Cité, CNRS, Institut Jacques Monod, Paris F-75013, France.

Proceedings of the National Academy of Sciences of the United States of America
|April 18, 2025
PubMed
概括

表皮细胞表现出一种新的固体集群行为,连贯地作为一个活跃的极性固体而不是流体移动. 这一发现揭示了对组织完整性和集体细胞迁移动态的新见解.

关键词:
有活性物质的活性物质.细胞力学 细胞力学集体细胞迁移 集体细胞迁移皮质细胞是表皮细胞.

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科学领域:

  • 细胞生物学 细胞生物学
  • 生物物理学的生物物理.
  • 软物质物理学 软物质物理学

背景情况:

  • 集体上皮细胞运动对于发育和疾病至关重要.
  • 在上皮细胞中大规模聚集主要被建模为类似流体的.
  • 未充分探索的集体运动模式可能会影响组织完整性.

研究的目的:

  • 识别和描述大规模集体上皮质细胞运动的新模式.
  • 为了研究表皮细胞集体行为超出流体动力学的物理性质.
  • 了解不同集体运动阶段对组织完整性的影响.

主要方法:

  • 在不同类型的上皮细胞中进行体外单个细胞跟踪.
  • 分析细胞运动模式,密度波动和速度相关性.
  • 基于活性极性固体框架的理论建模.

主要成果:

  • 确定了一个独特的集体细胞运动模式:极地活性固体群.
  • 观测到远距离的极地顺序,无尺度的速度相关性和剪切波.
  • 在大型系统中展示了不同的弹性变形波动,表明了破裂的可能性.

结论:

  • 表皮细胞可以表现出固体状的集体运动,具有独特的物理特征.
  • 在活跃的极性固体中,无质量定向的戈德斯通模式驱动着观察到的现象.
  • 固体群动力学可能导致大规模组织破裂和完整性丧失.