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Updated: May 11, 2025

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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pH驱动膜插入的生物物理学:对pHLIP的审查

Raiza Maia1, Kenichi Ataka2, Joachim Heberle2

  • 1Department of Chemistry, University of Texas at Austin, 105 E 24th St. A5300, Austin, Texas 78712, United States.

The journal of physical chemistry. B
|April 18, 2025
PubMed
概括

低pH插入 (pHLIP) 从可溶性过渡到嵌入膜的状态. 先进的方法揭示了其pH驱动的折叠机制,以及在生物医学应用中瘤向的潜力.

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
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