乳腺癌的印度妇女患者报告结果的时间演变:一项纵向研究
Suman Ghosh1, Tabassum Wadasadawala1, Sanjay Mohanty2
1Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.
JCO global oncology
|April 18, 2025
概括
这项关于印度乳腺癌幸存者的研究发现,大多数经历了治疗后改善的生活质量. 社会人口统计学因素,而不是治疗类型,是乳腺癌患者康复的关键预测因素.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 生活质量研究 研究 生命质量研究
背景情况:
- 乳腺癌 (BC) 是印度女性的主要恶性瘤.
- 了解BC幸存者的健康相关生活质量 (HRQoL) 演变是非常重要的,因为幸存率很高.
- 印度BC患者HRQoL的纵向数据有限.
研究的目的:
- 为了前性地评估印度乳腺癌患者HRQoL的纵向变化.
- 在这个人群中确定HRQoL轨迹的预测因素.
- 提供关于印度乳腺癌幸存者护理的见解.
主要方法:
- 500名印度乳腺癌患者的前性观察研究 (2019年6月-2022年3月).
- HRQoL使用EORTC-QLQ-C30,EORTC-QLQ-BR-23和EQ-5D-5L在治疗前,治疗后和6个月随访时进行评估.
- 线性混合效应建模用于分析HRQoL趋势和影响因素.
主要成果:
- 大多数患者 (60.8%) 患有局部晚期疾病,并接受多模式治疗.
- 全球QOL略有下降,但社会,认知和角色功能显著改善.
- 身体形象和性享受恶化;随着放射治疗,疲劳增加.
- 年轻的年龄,高等教育和财务独立预测了更好的HRQoL.
- 社会流离失所对QOL轨迹产生了负面影响.
结论:
- 这是印度BC患者的第一个纵向HRQoL研究,表明大多数功能领域的早期生存率有所改善.
- 社会人口统计学因素 (年龄,社会流离失所,教育,财务独立) 是比治疗方式更强的HRQoL预测因素.
- 建议进行进一步的长期随访,以全面评估印度BC幸存者的HRQoL.
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