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人类调节性B细胞抑制自身免疫性疾病,主要通过互白素-37抑制自身免疫性疾病
Luman Wang1, Maria-Ioanna Christodoulou2, Zheng Jin3
1Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Journal of autoimmunity
|April 18, 2025
概括
产生中白素-37的调节性B细胞 (Bregs) 显示出增强的抗炎作用. 它们在牛皮的频率降低表明它们对炎症性疾病具有治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 调控性B细胞 (Bregs) 是免疫平衡和炎症控制的关键.
- 介质素-10 (IL-10) 传统上被认为是Bregs的主要抑制因子.
- 人与小鼠之间的Bregs功能差异,特别是疾病的功能差异,仍然不清楚.
- 介素-37 (IL-37) 是一种免疫抑制性细胞因子,在人类中发现,而不是小鼠.
研究的目的:
- 描述人类IL-37产生的Bregs的特征和功能.
- 调查由重组IL-37 (rIL-37) 和CpG诱导的Bregs中的IL-37产生机制.
- 评估IL-37+ Bregs在炎症条件下的治疗潜力.
主要方法:
- 在人类Bregs中诱导IL-37的产生,使用rIL-37和/或Toll-like受体9主因子CpG.
- 分析IL-37和IL-10的产生,Bregs的扩散和HIF-1α的参与.
- 在体外和体外模型 (牛皮,结肠炎) 中评估IL-37+ Bregs的抗炎疗效.
- 在患有牛皮的患者中量化IL-37+Bregs频率.
主要成果:
- IL-37+ Bregs在人类中自然存在,可以通过rIL-37或CpG诱导.
- 单独IL-37促进IL-37的产生和Bregs的扩散,独立于IL-10.
- CpG通过HIF-1α诱导布雷格斯的IL-37表达,独立于IL-10.
- 与IL-37-Bregs相比,IL-37+Bregs显示出更强的抗炎作用.
- 在牛皮患者中观察到IL-37+ Bregs的频率下降.
结论:
- IL-37+ Bregs 具有强大的抗炎性质.
- IL-37+ Bregs代表了一种有前途的治疗策略,用于治疗牛皮和结肠炎等炎症性疾病.
- 向或增强IL-37+ Bregs可能有助于控制自身免疫和炎症性疾病.
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