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Updated: May 11, 2025

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使用人工神经网络在蛋白质染色学中加速机械模型校准

Dominik Voltmer1, Tinu Koshy1, Raena Morley1

  • 1Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.

Journal of chromatography. A
|April 18, 2025
PubMed
概括

本研究引入了人工神经网络 (ANN) 辅助的工作流程,以加快单克隆抗体 (mAb) 染色学机械模型的校准. 该方法有效估计模型参数,减少生物工艺开发中的瓶.

关键词:
人工神经网络的人工神经网络阴离子交换色谱学 阴离子交换色谱学复杂的抗体混合物.机械模型校准的方法参数估计的参数估计.绝缘质量作用异热体.

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Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
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