人类乳头瘤病毒阴性口腔癌的治疗结果:一个元分析
Smriti Panda1, Kurinchi S Gurusamy2, Alok Thakar3
1Department of Head and Neck Surgery, National Cancer Institute-All India Institute of Medical Sciences, New Delhi, India.
概括
前置手术似乎对HPV阴性口腔癌的生存率优越,但混偏差是一个问题. 需要更多关于HPV阴性OPSCC治疗的毒性和生活质量的数据.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
- 临床试验分析
背景情况:
- 阴性HPV口腔状细胞癌 (OPSCC) 在亚洲很常见.
- 治疗指南往往缺乏针对HPV阴性OPSCC的具体证据.
- 目前的方法主要基于HPV相关OPSCC的数据.
研究的目的:
- 系统地审查和对HPV阴性OPSCC的治疗选择进行元分析.
- 为了比较不同初级治疗干预措施的疗效.
- 为了确定这个患者群体的最佳治疗策略.
主要方法:
- 在2009-2023年期间搜索了多个数据库 (CENTRAL,MEDLINE,EMBASE) 和试验注册表.
- 包括随机对照试验 (RCT) 和非随机研究.
- 使用随机效应模型进行元分析.
主要成果:
- 包括47项研究 (12项RCT,35项非随机化).
- 前置手术显示了较好的整体存活率 (HR:0.63) 和无病存活率 (HR:0.48) 与非手术选择相比.
- 指出存在偏差的高风险;毒性和生活质量数据不足以进行元分析.
结论:
- 前部手术在HPV阴性OPSCC中显示出优异的OS和DFS.
- 观察到的生存益处可能会受到混偏差的影响.
- 关于毒性和生活质量的稀疏报告限制了最终的结论.
关键词:
化疗 化疗是一种化学疗法.人类乳头瘤病毒人类乳头瘤病毒.耳鼻喉 (oropharynx) 是一个辐射疗法 辐射疗法状细胞癌瘤是一种状细胞癌.跨口腔机器人手术是如何进行的人类乳头瘤病毒 (HPV) 阴性口腔支状细胞癌的治疗结果:元分析.更多相关视频
06:57Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
10.3K
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
9.6K
相关概念视频
Cancer Therapies
7.4K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.4K
Cancer Survival Analysis
298
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
298
Cancer Vaccines
238
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
238
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Tumor Immunotherapy
398
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
398
