鸟类的光受体同质性和双的起源
Yu Liu1, Erica C Hurley1, Yohey Ogawa1
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Current biology : CB
|April 18, 2025
概括
鸟类的光受体,包括双体 (DC-P和DC-A),具有复杂的进化起源. 研究表明DC-P是从祖先的红色体进化而来的,DC-A是从祖先的蓝色体进化而来的,与其他脊椎动物的视觉系统不同.
科学领域:
- 进化生物学是进化的生物学.
- 进行比较的基因组学.
- 视觉科学 视觉科学 视觉科学
背景情况:
- 鸟类表现出一个独特的脊椎动物光受体系统,有六种型.
- 鸟类光受体的进化历史在很大程度上仍未被探索.
- 了解这些关系,可以了解脊椎动物视觉系统的演变.
研究的目的:
- 研究鸟类光受体,特别是双的进化起源.
- 为了追踪鸟类和其他脊椎动物的光受体之间的细胞类型的同质性.
- 为了阐明DC-P和DC-A细胞的独特进化路径.
主要方法:
- 在视网膜上进行单细胞RNA测序 (scRNA-seq).
- 对转录因子 (TF) 的差异基因表达分析.
- 在CRISPR中介的基因淘汰和cis-regulatory分析.
主要成果:
- 鸟类的杆子和单独的体与鱼类和胎盘哺乳动物具有同质性.
- 双 (DC-P和DC-A) 具有不同的进化起源.
- DC-P表达签名与祖先的红色 (THRB,SAMD7) 相连;DC-A签名与祖先的蓝色 (FOXQ2,SKOR1) 相连.
- 在CRISPR中,THRB的淘汰会影响红和DC-P,而不是DC-A.
- 有证据表明,单独的增强剂可以控制DC-P和DC-A中的素表达.
结论:
- 鸟类的双 (DC-P和DC-A) 分别独立于祖先的红色和蓝色产生.
- 这些发现突出显示了Sauropsida.在内的光感受器的保存进化.
- 这项研究阐明了脊椎动物视觉系统复杂的进化轨迹.
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