怀孕中的母性喘和女儿和儿子的青春期时间:基于人口的队列研究
Camilla Lomholt Kjersgaard1, Andreas Ernst2, Sofie Aagaard Sand1
1Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, Aarhus 8000, Denmark.
Annals of epidemiology
|April 18, 2025
概括
母亲喘在男孩中稍微延迟了约一个月的青春期时间,但在女儿中没有发现显著的影响. 这一发现表明,母亲喘对男性青春期发育有潜在的影响,尽管很小.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 儿科健康 儿科健康
- 流行病学 流行病学
背景情况:
- 孕产妇喘患病率显著,但其对后代青春期时间的影响尚不清楚.
- 青春期是对环境和母亲健康因素敏感的关键发育时期.
研究的目的:
- 调查怀孕期间母亲喘与儿童青春期发育时间之间的联系.
- 探索潜在的调解因素,如出生体重和儿童喘.
主要方法:
- 利用了来自丹麦国家出生队列 (DNBC) 和丹麦国家患者登记册的数据.
- 通过 Puberty Cohort 中的半年评估评估青春期时间,涵盖各种发展里程碑的 Tanner 阶段.
- 采用了统计分析,包括调整的平均年龄差异,负控制和调解分析.
主要成果:
- 在喘母亲的儿子身上观察到稍微延迟的青春期发育 (平均1.0个月的差异).
- 对于女儿来说,没有发现任何显著的关联.
- 调解分析表明,出生体重和儿童喘并不能解释在男孩中观察到的相关性.
结论:
- 怀孕期间母亲的喘与儿子的青春期时间稍微延迟有关.
- 在男孩中观察到的关联并非由出生体重或儿童喘介导.
- 这些发现表明,母亲喘和男性青春期发育之间存在潜在的,尽管可能很弱的联系,需要进一步调查.
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