关于RIFM香料成分安全性评估的最新情况,4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -one,CAS注册编号为51519-65-45
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
概括
这项研究发现4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -one是安全的,没有遗传毒性,生殖毒性或皮肤敏感性问题. 环境风险系数也低于监管值,这表明环境安全.
科学领域:
- 毒理学和环境安全评估
- 化学品安全和风险评估
背景情况:
- 对于消费品中使用的化学品而言,全面的安全评估至关重要.
- 了解4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -one的毒理特征对于其安全应用至关重要.
研究的目的:
- 为了评估4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -one的基因毒性,重复剂量毒性,生殖毒性,局部呼吸系统毒性,光刺激/光过敏性,皮肤敏感性和环境安全性.
- 为了确定暴露水平是否低于相关毒性终点的毒理关注值 (TTC).
- 评估环境影响,包括持久性,生物积累和毒性 (PBT) 标准和风险系数.
主要方法:
- 基因毒性通过标准测定进行评估.
- 对克莱默III类物质的重复剂量,生殖和局部呼吸系统毒性使用毒理关注门 (TTC) 方法进行了评估.
- 皮肤敏感性是从结构模拟的阅读交叉方法确定,建立一个没有预期的敏感性诱导水平 (NESIL).
- 使用现有数据和UV/Vis光谱来评估光刺激/光过敏性.
- 根据国际香料协会 (IFRA) 的环境标准进行了环境安全评估,包括PBT评估和预测环境度/预测无效度 (PEC/PNEC) 比率的计算.
主要成果:
- 4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -一个没有表现出基因毒性.
- 证实暴露水平低于重复剂量,生殖和局部呼吸道毒性TTC.
- 5300μg/cm2的高NESIL表明皮肤敏感性的潜力很低.
- 发现该物质不具有光刺激性或光过敏性.
- 环境评估证实该物质不是持久性,生物积累性和有毒性 (PBT),其PEC/PNEC比率低于1.
结论:
- 4,4a,6,7,8,8a-hexahydro-1,4-methanonaphthalen-5(1H) -一个具有有利的安全概况.
- 该化学物质在基因毒性,全身毒性和局部影响方面被认为是安全的.
- 根据目前的使用量,与该物质相关的环境风险被认为是可以忽略不计的.
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