医疗气体血改变了糖尿病伤口愈合中的Nrf2信号传递
Anke Schmidt1, Lea Miebach1, Can Bagli1
1ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), a member of the Leibniz Health Research Alliance, Felix-Hausdorff-Str. 2, Greifswald 17489, Germany.
Journal of advanced research
|April 18, 2025
概括
医学气体血疗法通过激活Nrf2通路,在糖尿病小鼠中加速伤口愈合. 这种方法有望通过减少炎症和氧化应激来治疗糖尿病和非糖尿病伤口.
科学领域:
- 生物医学工程 生物医学工程
- 伤口治愈研究研究 伤口治愈研究
- 血医学是一种血医学.
背景情况:
- 糖尿病会影响生理伤口愈合过程.
- 医疗气体等离子技术利用反应性物种促进伤口修复.
- 核因素红色素2相关因子2 (Nrf2) 激活与糖尿病并发症的改善有关.
研究的目的:
- 研究医疗气体等离子体在糖尿病伤口愈合中的治疗潜力和机制.
- 评估Nrf2信号在气体等离子体中介伤口修复中的作用.
- 在糖尿病模型中评估气体等离子体对炎症和氧化应激的影响.
主要方法:
- 在II型糖尿病和野生型小鼠中产生全厚皮肤伤口.
- 使用光学发射光谱学分析了等离子体反应性物种.
- 在小鼠和人类伤口样本中评估了Nrf2信号,基因表达 (qPCR),蛋白质水平和细胞因子分泌.
主要成果:
- 在糖尿病小鼠中,医疗气体血治疗加速了伤口再上皮化.
- 气体等离子体激活了Nrf2信号传递,这对伤口愈合至关重要,Nrf2淘汰赛研究证实了这一点.
- 血疗法调节了局部和全身细胞因子水平,减少了炎症.
- 在人类糖尿病伤口中,Nrf2信号受保护于氧化应激,重复治疗可以减少炎症媒介.
结论:
- 医疗气体血疗法显著加速伤口愈合.
- Nrf2激活是气体等离子体治疗作用的关键机制.
- 气体血疗法在治疗糖尿病和非糖尿病伤口方面具有很高的潜力.
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