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在亚急性乳头酸性疾病之前和之后,在乳牛中研究牛寄居性免疫细胞具有挑战性
K C Krogstad1, M P Bernard2, B Hill3
1Department of Animal Science, Michigan State University, East Lansing, MI 48824; Department of Animal Science, The Ohio State University, Wooster, OH 44691.
Journal of dairy science
|April 18, 2025
概括
免疫细胞,主要是T淋巴细胞,存在于乳牛的皮上皮. 它们的数量在酸化挑战期间没有变化,这表明它们在皮组织中存在稳定状态.
科学领域:
- 动物生理学和免疫学
- 胃肠道免疫细胞局部化
- 乳牛的健康和营养 乳牛的健康和营养
背景情况:
- 免疫细胞存在于各种哺乳动物组织中,包括肠道.
- 免疫细胞在分层皮表皮中的存在和作用尚不清楚.
- 乳汁酸是高产奶牛中常见的代谢障碍.
研究的目的:
- 为了确定免疫细胞是否存在于健康的哺乳乳乳牛的乳头上皮.
- 为了调查白细胞群体在肠酸性疾病挑战期间的变化.
- 为了识别 rumen papillae 内免疫细胞的位置和类型.
主要方法:
- 一个分为两个阶段的实验,使用了九只经过反通道注射的哺乳期霍尔斯坦牛.
- 牛被养的是控制饮食 (CON) 或酸诱导饮食 (AID),旨在降低小肠的pH值.
- 血液,血液,便和血组织样本被收集用于分析;免疫细胞的存在和表型被评估.
主要成果:
- 酸诱导饮食成功地降低了小牛皮的pH值.
- 尽管饮食发生了变化,但原免疫细胞 (白细胞) 的总数和比例在CON和AID阶段之间没有差异.
- CD3+ T 淋巴细胞是主要的免疫细胞,被确定在皮皮内,位于自身层,基层和脊层.
结论:
- T淋巴细胞是乳牛牛皮上皮的免疫细胞群中的重要组成部分.
- 这些免疫细胞的存在似乎是稳定的,并没有显著地改变短期的肠酸性疾病.
- 对反动物白细胞的功能进行进一步的研究可以提供有关反动物肠道健康和免疫功能的见解.
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