辅助内福帕姆与机械通风手术重症患者的标准护理:一项随机,双盲对照研究
Mohammed Gamal Abdelraouf1, Samar Farghali Farid2, Ahmed Mohammed Mukhtar3
1Department of Clinical Pharmacy, Cairo University Hospitals (Kasr Al Ainy), Cairo University, Cairo 11559, Egypt.
Anaesthesia, critical care & pain medicine
|April 18, 2025
概括
在机械通风患者中,辅助内福帕姆输液显著降低了阿片类药物消耗. 这种非阿片类止痛药为重症监护治疗提供了一个有希望的替代方案.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 麻醉学 麻醉学
背景情况:
- 多模式止痛疗法通过准不同的疼痛途径来减少阿片类药物的使用.
- 机械通风的重症患者通常需要显著的止痛和镇静.
- 在重症监护中,节约阿片类药物的策略至关重要,以减轻不良影响.
研究的目的:
- 评估将内福帕姆输液添加到标准护理对阿片类药物消费的影响.
- 评估nefopam作为机械通风ICU患者的辅助止痛药的疗效和安全性.
主要方法:
- 前性,随机化,主动控制,双盲研究设计.
- 包括需要止痛和镇静的机械通风ICU患者.
- 主要结局:在前24小时内累积的芬太尼剂量;次要结局:疼痛评分,血液动力学参数和ICU死亡率.
主要成果:
- 在内福帕姆组 (p=0.001) 中,芬太尼的中位数消耗显著降低 (1300比2400mcg/24h).
- 在nefopam和对照组之间可比的疼痛和镇静得分.
- 在ICU死亡率上没有统计学上显著的差异 (83.3%与66.7%,P=0.136).
结论:
- 尼福帕姆是机械通风手术和创伤患者的有效非阿片类止痛药.
- 尼福帕姆在重症监护中显示出作为多模式止痛的一部分的潜力.
- 进一步的研究是有必要的,以充分阐明nefopam在这个人群中的安全性.
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