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可喷涂氧化纤维素纳米纤维水凝,具有快速静血能力,用于皮肤伤口愈合
Le Wang1, Ya Liu2, Wentao Duan3
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
International journal of biological macromolecules
|April 18, 2025
概括
这项研究开发了一个可喷的水凝,仅使用TEMPO介导的氧化纤维素纳米纤维 (TOCN) 和水. 在临床前模型中,TOCN水凝有效地实现了快速血静,并促进了显著的皮肤伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 纳米技术纳米技术
背景情况:
- 有效的血液静止对于伤口愈合和组织再生至关重要.
- TEMPO介导的氧化纤维素纳米纤维 (TOCN) 在静血材料中使用,但它们作为喷水凝中唯一成分的潜力尚未得到充分探索.
研究的目的:
- 制定和评估一种新型的喷水凝,仅用TOCN和用于血液静止和皮肤伤口修复的水进行喷.
- 在体外和体内评估TOCN水凝的静血和再生能力.
主要方法:
- 使用TOCN和通过超声波碎片化用水制备可喷的水凝.
- 在体外生物相容性和凝血测试.
- 在大鼠肝脏 (血液静止) 和皮肤缺陷 (伤口愈合) 模型中的体内评估.
- 在猪伤口模型中进行验证.
主要成果:
- TOCN水凝在水中形成了一个稳定的,非交叉连接的3D网络,具有出色的生物相容性和凝固特性.
- 在大鼠肝脏模型中,与甲基酸盐相比,血静性能优越.
- 在大鼠中,在第15天之前,皮肤伤口完全关闭,皮肤/表皮组织 (包括附属物) 再生.
- 在猪模型中验证了显著的静血和伤口愈合促进.
结论:
- 一种仅由TOCN和水组成的可喷水凝显示出强大的静血能力.
- TOCN水凝有效促进皮肤伤口的快速和完整愈合,包括复杂组织结构的再生.
- 这种基于TOCN的水凝对于血液静止和先进的皮肤修复应用具有显著的临床潜力.
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