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治疗和未治疗的孕产妇肥胖症的原性风险

Robert E Jones¹, Chloe A Zera²

¹Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02115, United States.

Seminars in perinatology

|April 18, 2025

概括

没有治疗的妊娠肥胖会损害后代的长期健康. 新的抗肥胖药物,如葡萄糖类1受体激动剂 (GLP-1RA),在怀孕早期显示出潜在的安全性,提供新的咨询途径.

科学领域:

生殖医学生殖医学
内分泌学在内分泌学.
公共卫生公共卫生

背景情况:

怀孕期间未经治疗的肥胖会导致胎儿和新生儿的不良后果,影响后代的长期健康,并将肥胖症延续到代后代.
目前的孕前减肥策略在很大程度上无效地减轻这些风险.
抗肥胖药物 (AOMs) 在怀孕期间没有得到充分的研究,因为担心产性,目前的指导方针往往忽视了肥胖是一种慢性疾病.

研究的目的:

审查母亲肥胖对后代健康的风险.
讨论当前和新兴的妊娠肥胖治疗策略.
在怀孕前和怀孕期间,为以患者为中心的咨询提供有关AOM,特别是GLP-1RA的指导.

主要方法:

关于与孕产妇肥胖相关风险的文献综述.
对当前预孕和产前护理策略的分析.
关于AOMs的证据评估,重点是GLP-1RA,在怀孕的背景下.

主要成果:

孕产妇的肥胖会给后代带来重大的长期健康风险,包括肥胖和心脏代谢疾病.
现有的怀孕前干预措施的有效性有限.
新出现的证据表明GLP-1RA在怀孕早期的潜在安全性和有效性,需要进一步研究.

结论:

怀孕期间的肥胖需要一种慢性疾病管理方法.
GLP-1RA是一种有希望的,但尚未研究的AOM类,用于在怀孕前和怀孕早期管理肥胖.
进一步的研究对于确定安全性和有效性至关重要,为提供者提供知情,以患者为中心的咨询.

关键词:

抗肥胖药物抗肥胖药物作为GLP-1受体的激动剂.代谢和减肥手术的代谢和减肥手术.偏见减肥减肥偏见减肥产性产性产性

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