这是一种多学科的方法,用于对虚拟人类肺部进行建模
Timothy Lam1, Henry T Quach1,2, Lauren Hall1,2
1Program in Developmental, Stem cell and Cancer Biology, Hospital for Sick Children, PGCRL 16-9420, Toronto, ON, Canada.
NPJ systems biology and applications
|April 18, 2025
概括
通过整合生物数据和in silico建模来创建数字双胞胎有助于疾病理解和治疗发现. 本次审查强调了开发数字肺双胞胎的进展,特别是对于具有有限模型的疾病.
科学领域:
- 计算生物学是一种计算生物学.
- 系统生物学 系统生物学
- 生物信息学是一种生物信息学.
背景情况:
- 虚拟人体模型,或数字双胞胎,将生物数据与in silico建模集成在一起.
- 这些模型为了解疾病和开发新型治疗策略提供了变革性的潜力.
- 这种方法对于缺乏可靠实验模型的疾病尤其有价值.
研究的目的:
- 审查人类肺部发育当前的建模工作.
- 突出跨学科合作在推进数字双胞胎技术中的作用.
- 讨论创建数字肺双胞胎的关键进展.
主要方法:
- 审查现有的关于in silico建模和数字双胞胎开发的文献.
- 对生物数据集成的跨学科方法的分析.
- 人类肺部发育建模的关键进展的综合.
主要成果:
- 生物数据和in silico建模的整合对于虚拟人类模型至关重要.
- 数字双胞胎在疾病研究和治疗开发方面显示出重大前景.
- 正在向全面的数字肺双胞胎取得进展.
结论:
- 数字双胞胎是推动生物医学研究的强大工具.
- 跨学科的合作对于成功开发复杂的生物模型至关重要.
- 数字肺双胞胎是一个新兴的前沿,有可能彻底改变呼吸系统医学.
相关概念视频
01:47Lung Capacity
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
01:17Gross Anatomy of the Lungs
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...