相关实验视频

Updated: May 11, 2025

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

瘤溶解性病毒疗法为状膀癌提供了一种有效的治疗选择

Julia Pannhausen^1,2, Julia Wirtz^1,2, Klaus Mantwill³

¹Institute of Pathology, Uniklinik RWTH Aachen, 52074, Aachen, Germany.

Scientific reports

|April 18, 2025

概括

用腺病毒XVir-N-31进行瘤性病毒疗法显示出治疗膀平细胞癌 (SCC) 的前景. 临床前研究证实了通过利用Y-Box结合蛋白1 (YB-1) 表达来准SCC的疗效.

科学领域:

瘤治疗性病毒疗法
膀癌研究的研究
状细胞癌 (SCC) 治疗方法

背景情况:

膀平细胞癌 (SCC) 的有限有效治疗选择会影响患者的预后.
瘤溶解性病毒疗法是膀癌的有希望的方法,FDA对非侵入性高度膀癌 (BLCA) 进行了指定.
临床前研究表明,瘤性腺病毒XVir-N-31在尿路细胞癌 (UC) 中具有有效性,但其在SCC中的潜力尚未被探索.

研究的目的:

评估瘤性腺病毒XVir-N-31作为膀状细胞癌 (SCC) 的新疗法的疗效.
研究Y-Box结合蛋白1 (YB-1) 在促进SCC中的Xvir-N-31复制中的作用.

主要方法:

分析了TCGA BLCA队列中的YB-1mRNA表达,并将其与患者的结果相关联.
在89个SCC样本中进行了YB-1的免疫组织化学染色.
在特定亚型的细胞培养体内评估XVir-N-31感染,复制和细胞杀伤能力.
在使用患者衍生的SCC和UC细胞系的新型卵巢外移植模型中评估了Xvir-N-31的疗效.

主要成果:

在BLCA的基底/状亚型中检测到YB-1mRNA表达的增加,与患者的结果相关.
在状BLCA (sq-BLCA) 中通过免疫组织化学证实了强烈的YB-1表达.
XVir-N-31在体外显示出高的感染,复制和细胞杀死率.
在卵外移植中,XVir-N-31显著抑制了生长 (39-49%).

结论:

临床前数据支持XVir-N-31在膀状细胞癌 (SCC) 的型病毒疗法的高疗效.
YB-1表达是SCC中Xvir-N-31治疗的潜在生物标志物.
XVir-N-31代表了膀SCC的一个有前途的新疗法策略.

关键词:

膀癌是一种癌症.瘤学病毒病毒.状细胞癌瘤是一种状细胞癌.病毒疗法病毒疗法在XVir-N-31中使用.YB-1 是一个YB-1.

更多相关视频

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

相关概念视频

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...