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孟德尔的睡眠特征和结直肠癌风险的随机化研究
Olympia Dimopoulou1,2, Harriett Fuller3, Rebecca C Richmond4,5
1Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. olympia.dimopoulou@bristol.ac.uk.
Scientific reports
|April 18, 2025
概括
基因预测的早晨偏好可能会降低男性的结直肠癌 (CRC) 风险,但整体睡眠特征与CRC风险几乎没有关联. 需要进一步的研究来证实这些发现.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 时间生物学 时间生物学
背景情况:
- 循环节律的破坏是潜在的癌症风险因素.
- 关于睡眠特征和结直肠癌 (CRC) 风险的流行病学数据有限且相互矛盾.
研究的目的:
- 调查基因预测的时间型,失眠和睡眠时间与CRC风险之间的关联.
- 通过使用孟德尔随机化 (MR) 来分析男性,女性,整体和CRC解剖学子站点的这些关联.
主要方法:
- 采用了两个样本的逆方差加权 (IVW) 门德尔随机化 (MR) 方法.
- 利用了睡眠特征的全基因组关联数据和最多58,221例CRC病例和67,694例对照的总结级数据.
- 使用替代仪器进行二次分析和灵敏度分析,以评估MR假设的违反.
主要成果:
- 基因预测的早晨偏好与男性CRC风险降低13%有关 (OR_IVW = 0.87,P = 0.01).
- 这种关联在女性或两性中都没有观察到,并且在一些,但不是所有的灵敏度分析中保持一致.
- 其他睡眠特征 (失眠,睡眠时间) 与CRC风险没有发现显著的关联.
结论:
- 这项研究为基因预测的睡眠特征与结直肠癌风险之间的关联提供了有限的证据.
- 一个潜在的保护性协会为早晨的男性时代型值得进一步调查.
- 总的来说,遗传预测的睡眠特征似乎与CRC风险没有很强的关联.
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