饮食中的酸负荷和膝关节骨关节炎的几率:一个病例对照研究
Soudabeh Hamedi-Shahraki1, Jalal Moludi2, Hawal Lateef Fateh3
1Department of Epidemiology and Biostatistics, School of Public Health, Zabol University of Medical Sciences, Zabol, Iran.
Scientific reports
|April 18, 2025
概括
高食酸负荷 (DAL) 与40岁以上成年人膝关节骨关节炎 (KOA) 风险增加有关. 通过饮食减少DAL可能有助于管理这种常见的关节炎疾病.
科学领域:
- 营养科学 营养科学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 膝关节骨关节炎 (KOA) 是一种常见的退行性关节疾病,导致疼痛和流动性丧失,特别是在老年人群中.
- 新兴研究表明,饮食中的酸负荷 (DAL) 可能通过系统性炎症促进KOA的发病.
- 了解DAL等可修改的饮食因素对于KOA预防和管理策略至关重要.
研究的目的:
- 调查40岁及以上的成年人中饮食酸负荷 (DAL) 和患膝关节关节炎 (KOA) 的风险之间的关联.
- 为了确定更高的DAL是否独立地与KOA的几率增加有关.
- 探索DAL和KOA之间的关系中的潜在性别特异性差异.
主要方法:
- 一个病例控制研究,涉及150例新诊断的KOA病例和300个匹配的对照 (年龄≥40) 来自伊朗扎博尔县.
- 通过经过验证的食物频率问卷评估的饮食摄入量来计算DAL.
- 后勤回归分析用于估计DAL四分位数中KOA的几率比率 (OR),调整为体力活动,吸烟和补充剂使用.
主要成果:
- 在DAL的最高四分位数中,与最低四分位数相比,经过混调整后,DAL的最高四分位数中的个体表现出明显更高的KOA几率 (OR: 2.48,95%CI: 1.36-4.51).
- 观察到一种剂量与反应的关系,增加DAL四分位数与男性 (OR:2.52) 和女性 (OR:2.55) 的高KOA几率相关.
- 在对潜在的混变量进行调整后,这种关联仍然显著.
结论:
- 这项研究提供了证据表明,高食酸负载与膝关节骨关节炎的几率增加之间存在显著的关联.
- 减少DAL的饮食修改可能是减轻KOA风险的可行策略,特别是在老年人中.
- 进一步的纵向研究是有必要的,以确定因果关系,并探索连接DAL和KOA的潜在机制.
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