在国家癌症数据库中调整人口差异以更好地代表美国癌症病例:研究人员的参考工具
Anays Murillo1,2, Kelsey S Romatoski1,2, Sophie H Chung1,2
1Section of Surgical Oncology, Department of Surgery, Boston Medical Center, Boston, MA, USA.
Annals of surgical oncology
|April 18, 2025
概括
国家癌症数据库 (NCDB) 显示,美国的癌症病例代表性正在改善,但不完整. 需要进行调整,以解决在特定的人口统计和地点的不足,以获得准确的癌症结局研究.
科学领域:
- 癌症研究 癌症研究
- 分析健康结果分析
- 数据库的使用情况.
背景情况:
- 国家癌症数据库 (NCDB) 是美国癌症结果研究的关键资源.
- 依靠癌症委员会批准的医院导致某些人群的代表性不足,并限制了概括性.
- 关于NCDB代表性的现有文献已经过时了,直到2014年.
研究的目的:
- 调整NCDB癌症病例,以更好地反映美国总癌症人口.
- 为改善NCDB数据对癌症结局研究的有用性提供一种方法.
主要方法:
- 将NCDB事件癌症病例 (2016-2020年) 与美国癌症统计局 (USCS) 综合数据库进行比较.
- 定义NCDB案例覆盖率作为在NCDB中代表的USCS案例的百分比.
- 对年龄,性别,种族/民族,居住地和癌症部位进行了分分析.
主要成果:
- 在5年 (2016-2020年) 中,NCDB覆盖率为70%,从68%增加到73%.
- 男性,85岁以上的个人,美国印第安人/阿拉斯加土著人和西班牙裔/拉丁裔个人 (分别为65%,59%,42%,55%) 的覆盖率最低.
- 山区 (49%) 和非大都会地区 (64%) 是代表性最低的地区;主要癌症类型的代表性也相似.
结论:
- NCDB对美国癌症病例的代表性正在改善,但仍存在重大差距.
- 在年龄,性别,种族/族裔和居住地之间存在代表性不足,缺失的数据加剧了这一现象.
- 该研究为研究人员提供了一种方法来调整NCDB数据,以便更定制的研究和结果框架.
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