一项前性队列研究,研究腹腔大动脉化和全身炎症反应指数与死亡风险的联合关联
Tianyi Ma1, Shupei Tang2, Denglu Zhou3
1Department of Emergency Medicine, Shigatse Branch, Xinqiao Hospital, Army Medical University, Shigatse, 857000, China.
Scientific reports
|April 18, 2025
概括
结合腹腔大动脉化 (AAC) 和全身炎症反应指数 (SIRI),可显著预测死亡风险. 患有AAC和SIRI升高的人面临所有原因和心血管疾病死亡的最高风险.
科学领域:
- 心血管流行病学心血管流行病学
- 生物标志物研究的研究.
- 公共卫生 公共卫生
背景情况:
- 腹腔大动脉化 (AAC) 和全身炎症反应指数 (SIRI) 个别与全因和心血管疾病 (CVD) 相关死亡率的增加有关.
- 在一般人群中,AAC和SIRI对不良结果的综合预测价值仍未得到充分研究.
研究的目的:
- 调查腹腔大动脉化 (AAC) 和全身炎症反应指数 (SIRI) 与所有原因和心血管疾病相关死亡风险的联合关联.
- 为了确定AAC和SIRI的结合是否提高了不良结果的预测.
主要方法:
- 使用2013-2014年国家健康和营养检查调查 (NHANES) 数据进行的前性队列研究.
- 按分数分类的AAC (非AAC,低中度AAC,严重AAC);SIRI分层的三分之一.
- 多变量考克斯回归和竞争性风险模型分析了协会,参与者按AAC存在/缺席和SIRI水平分组进行联合分析.
主要成果:
- 两种AAC (严重与非AAC:HR=2.903所有原因,HR=4.579心血管疾病相关死亡率) 和SIRI (三位数3与三位数1:HR=2.077所有原因,HR=3.215心血管疾病相关死亡率) 独立地与增加的死亡风险相关.
- 在相互调整后,这些关联仍然很重要.
- 具有AAC存在和SIRI升高的参与者表现出所有原因和CVD相关死亡率的最高风险.
结论:
- 严重的AAC和升高的SIRI是一般人群中所有原因和心血管疾病相关死亡率的独立风险因素.
- AAC和SIRI的组合为识别高风险个体提供了增强的预测价值.
- 对AAC和SIRI的联合评估可以完善对心血管不良结果的风险分层策略.
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